Advanced Paternal Age Linked to Increased Miscarriage Risk and Lower Live Birth Rates in Donor Egg IVF Cycles, New Study Reveals
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London, UK – June 29, 2025 – New research presented at the European Society of Human Reproduction and Embryology (ESHRE) 41st Annual Meeting has shed light on a concerning correlation between advanced paternal age and outcomes in assisted reproductive technologies, specifically donor egg In Vitro Fertilization (IVF) cycles. The study, published by PRNewswire, indicates that when the male partner is older, couples may face a higher risk of miscarriage and a reduced chance of a successful live birth.
This significant finding suggests that the age of the father, independent of the mother’s age or the age of the egg donor, plays a crucial role in the success rates of IVF treatment. While the impact of advanced maternal age on fertility and pregnancy outcomes is well-established, this research highlights that paternal age warrants equal consideration in fertility assessments and counseling.
The study’s findings are particularly relevant to individuals and couples undergoing donor egg IVF, a treatment often pursued by women who are unable to conceive using their own eggs. In these scenarios, the donor’s age is typically carefully managed, and the focus is often placed on the recipient’s reproductive health. However, this latest research emphasizes that the biological contribution of the father, even with a younger donor egg, can be significantly influenced by his own age.
While the exact biological mechanisms are still under investigation, it is understood that sperm quality and DNA integrity can decline with age. Older sperm may harbor more DNA fragmentation, which has been previously linked to reduced fertilization rates, impaired embryo development, and an increased risk of pregnancy loss.
The implications of this research are multifaceted. For individuals and couples considering fertility treatments, it underscores the importance of a comprehensive evaluation that includes the age of both partners. It may also prompt discussions around the optimal timing for conception or the utilization of fertility preservation techniques for men who plan to have children at a later age.
For fertility specialists and clinics, this study provides valuable data to enhance patient counseling and treatment protocols. Understanding these age-related paternal influences can help set more accurate expectations for success rates and inform personalized treatment strategies.
The ESHRE annual meeting serves as a vital platform for the dissemination of cutting-edge research in reproductive medicine, and this study is a testament to the ongoing efforts to improve understanding and outcomes in assisted reproduction. Further research is anticipated to delve deeper into the specific molecular pathways affected by paternal age and to explore potential interventions that could mitigate these risks.
This important discovery serves as a reminder that reproductive health is a complex interplay of factors, and the biological contribution of both parents is crucial for a successful pregnancy journey.
About ESHRE:
The European Society of Human Reproduction and Embryology (ESHRE) is a leading global organization dedicated to advancing the science and practice of human reproduction and embryology. It brings together professionals from around the world to share knowledge, promote research, and improve patient care.
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Disclaimer: This article is based on information released by PRNewswire regarding a study presented at the ESHRE 41st Annual Meeting. The information provided is for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
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