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Advanced Paternal Age Linked to Increased Miscarriage Risk and Lower Live Birth Rates in Egg Donation IVF Cycles
A recent study presented at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has shed light on a concerning correlation between advanced paternal age and outcomes in in-vitro fertilization (IVF) cycles utilizing donor eggs. The findings suggest that men of older age may face an elevated risk of miscarriage and a reduced chance of a successful live birth when their gametes are used in conjunction with donor oocytes.
The research, highlighted in a press release from PR Newswire on June 29, 2025, indicates that as a man’s age increases, so too does the likelihood of pregnancy loss following IVF treatment where donor eggs are employed. Correspondingly, the study observed a downward trend in the rate of live births as paternal age advanced. This suggests that biological factors associated with aging in men might impact embryo development and implantation even when the female gamete is from a younger, presumably more viable, donor.
While the precise biological mechanisms behind this association require further investigation, it is widely understood that sperm quality can decline with age. This decline can manifest in various ways, including potential increases in DNA fragmentation in sperm cells, which has been previously linked to poorer reproductive outcomes. The study’s findings underscore the importance of considering both maternal and paternal age in fertility treatments, even in cases where donor eggs are used to mitigate potential age-related challenges on the maternal side.
For individuals and couples considering fertility treatments, particularly those involving egg donation, this research serves as a valuable piece of information. It emphasizes the significance of comprehensive fertility assessments for both partners, regardless of the specific treatment protocol. Open and thorough discussions with fertility specialists are crucial to understanding individual risks and developing the most effective and personalized treatment plans.
The ESHRE annual meeting is a prestigious event that brings together leading experts in reproductive medicine to present groundbreaking research and discuss advancements in the field. Studies like this contribute significantly to our growing understanding of the complex factors influencing fertility and pregnancy outcomes, ultimately aiming to improve success rates and support individuals on their journey to parenthood.
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www.prnewswire.com published ‘ESHRE 41st Annual Meeting: L’âge paternel plus élevé est lié à un risque de fausse couche plus important et à des taux de naissance vivante plus faibles dans les cycles de FIV avec don d’ovules’ at 2025-06-29 22:01. Please write a detailed article about this news in a polite tone with relevant information. Please reply in English with the article only.