Promising One-Year Data from CAHtalyst™ Studies Presented by Neurocrine Biosciences at Endocrine Society Meeting
SAN DIEGO – July 14, 2025 – Neurocrine Biosciences, Inc. (NASDAQ: NBIX) recently shared significant one-year data from its Phase 3 CAHtalyst™ studies. These findings, presented at the 2025 Endocrine Society’s Annual Meeting, highlight the potential of a novel treatment to improve weight-related effects associated with glucocorticoid treatment in patients with classical congenital adrenal hyperplasia (CAH).
The presented data showcased encouraging results demonstrating a positive impact on weight management, a common and challenging side effect of long-term glucocorticoid therapy. Glucocorticoids are a cornerstone of treatment for CAH, a rare genetic disorder that affects hormone production by the adrenal glands. While essential for managing the condition, these medications can lead to various metabolic disturbances, including weight gain and Cushingoid features.
The CAHtalyst™ studies are pivotal in evaluating the efficacy and safety of Neurocrine Biosciences’ investigational treatment. The one-year follow-up data provided valuable insights into the sustained benefits of the therapy, particularly concerning the weight-related effects experienced by patients. By addressing these challenging side effects, Neurocrine Biosciences aims to offer a more comprehensive approach to managing classical CAH, potentially improving the overall quality of life for affected individuals.
The presentation at the Endocrine Society’s Annual Meeting underscores the scientific community’s keen interest in advancements for rare endocrine disorders. The detailed data shared by Neurocrine Biosciences’ researchers and clinicians offers a hopeful outlook for patients living with classical CAH, suggesting a potential new avenue for mitigating the significant impact of glucocorticoid treatment on body weight and metabolic health.
Neurocrine Biosciences remains committed to advancing the understanding and treatment of CAH. The company’s ongoing research and development efforts are focused on bringing innovative therapies to patients with unmet medical needs. Further analysis of the CAHtalyst™ study data is expected, with the potential for these findings to inform future treatment guidelines and patient care strategies.
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