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Imugene Reports Promising Response Rates in Phase 1b Trial of Azer-cel CAR T Therapy for Relapsed/Refractory DLBCL
Imugene Limited, a clinical-stage immuno-oncology company, has recently announced highly encouraging response rates from its Phase 1b clinical trial evaluating Azer-cel, an allogeneic Chimeric Antigen Receptor T (CAR T) cell therapy. The trial specifically focuses on patients with relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL) who have undergone three or more lines of treatment. The news, published byprnewswire.com on July 14, 2025, marks a significant milestone in the development of this novel therapeutic approach.
The preliminary data from the Phase 1b trial has demonstrated what Imugene describes as “outstanding response rates,” suggesting a strong potential for Azer-cel to offer a new and effective treatment option for individuals battling this aggressive form of non-Hodgkin lymphoma. DLBCL is a challenging disease, and for patients who have not responded to or have relapsed after multiple prior therapies, treatment outcomes can be limited. The development of allogeneic CAR T therapies, which utilize donor T-cells rather than the patient’s own, offers a potentially more accessible and readily available treatment pathway.
While specific numerical details regarding the response rates have not been elaborated upon in the provided context, the announcement of “outstanding” results typically indicates a high proportion of patients achieving a positive clinical outcome, which can include complete remission (CR) or partial remission (PR). These early indicators are crucial for advancing the therapy through further clinical development.
Imugene’s commitment to advancing innovative cancer treatments is underscored by this progress. The company’s focus on developing CAR T therapies like Azer-cel reflects the broader effort within the oncology community to harness the power of the immune system to fight cancer. The successful demonstration of efficacy in a challenging patient population like those with 3L+ DLBCL is particularly noteworthy.
The company’s continued work on Azer-cel is a testament to the ongoing research and dedication aimed at improving the lives of cancer patients. Further details regarding the trial’s outcomes and potential next steps are anticipated as Imugene continues to analyze the data and progress its clinical programs. This promising news offers a renewed sense of hope for patients and clinicians alike in the ongoing fight against Diffuse Large B-cell Lymphoma.
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www.prnewswire.com published ‘Imugene Announces Outstanding Response Rates from the Phase 1b Trial of the Az er-cel Allogeneic CAR T in 3L+ DLBCL’ at 2025-07-14 04:31. Please write a detailed article about this news in a polite tone with relevant information. Please reply in English with the article only.