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Ascletis Announces Completion of Dosing in U.S. Clinical Study for Novel Obesity Treatment Combination
Ascletis, a clinical-stage biotechnology company, has reached a significant milestone in its development of innovative therapies for obesity. The company announced today the successful completion of dosing for all participants in its U.S. clinical study. This study is investigating a promising combination therapy that pairs Ascletis’ adipose-targeted, once-monthly injectable small molecule THRβ agonist, ASC47, with semaglutide, a widely recognized and effective medication for weight management.
The clinical trial is designed to evaluate the safety and efficacy of this novel therapeutic approach, which aims to leverage the synergistic potential of targeting multiple pathways involved in metabolic regulation. ASC47 represents a targeted approach, focusing its action on adipose tissue, the body’s fat tissue, through its function as a thyroid hormone receptor beta (THRβ) agonist. This mechanism is understood to play a crucial role in fat metabolism and energy expenditure.
By combining ASC47 with semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist known for its ability to reduce appetite and improve glycemic control, Ascletis aims to offer a more comprehensive solution for individuals struggling with obesity. The study’s completion of participant dosing marks a critical step forward, enabling the researchers to gather valuable data on how this combination impacts key efficacy and safety endpoints.
This development is particularly encouraging given the ongoing need for effective and well-tolerated treatments for obesity, a complex chronic disease that affects millions worldwide. The potential for a once-monthly injectable formulation further adds to the attractiveness of this investigational therapy, offering convenience for patients.
Ascletis is committed to advancing the development of ASC47 and this combination therapy with the ultimate goal of providing new treatment options that can significantly improve the lives of patients living with obesity. Further updates on the study’s findings are anticipated as the data analysis progresses.
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www.prnewswire.com published ‘Ascletis Completes Dosing of All Participants in Its U.S. Clinical Study Combining Adipose-Targeted, Once-Monthly Injectable Small Molecule THRβ Agonist, ASC47, and Semaglutide for the Treatment of Obesity’ at 2025-07-14 23:00. Please write a detailed article about this news in a polite tone with relevant information. Please reply in English with the article only.