Sensorion Unveils Promising Preliminary Data from First Cohort of Audiogene Phase 1/2 Gene Therapy Clinical Trial
Paris, France – July 1, 2025 – Sensorion, a pioneering biotechnology company focused on developing novel therapies for hearing loss and other inner ear diseases, announced today encouraging preliminary data from the first cohort of its ongoing Phase 1/2 clinical trial for Audiogene, its gene therapy candidate for the treatment of hearing loss due to mutations in the OTOF gene.
The announcement, published by Business Wire French Language News, signals a significant step forward for Sensorion and for individuals suffering from genetic forms of deafness. The OTOF gene, when mutated, leads to a severe form of congenital hearing loss, affecting a considerable number of newborns worldwide. Audiogene aims to deliver a functional copy of the OTOF gene to the inner ear, thereby restoring the production of the otoferlin protein, which is crucial for auditory neurotransmission.
The preliminary results from the first cohort of patients enrolled in the Phase 1/2 trial have demonstrated a favorable safety profile for Audiogene. Importantly, the data also indicates early signs of therapeutic efficacy, suggesting that the gene therapy may be successful in improving hearing function in treated individuals. While Sensorion has not yet released extensive details on the specific endpoints met, the positive nature of these initial findings is generating considerable optimism within the scientific and patient communities.
This Phase 1/2 trial is designed to evaluate the safety, tolerability, and preliminary efficacy of different doses of Audiogene in patients with OTOF-mediated hearing loss. The study is being conducted in multiple centers, and the company is meticulously collecting and analyzing data to ensure a thorough understanding of the therapy’s performance.
The successful progression of Audiogene through these early clinical stages represents a beacon of hope for families impacted by this form of inherited hearing loss. Gene therapy holds immense potential to offer a one-time, potentially curative treatment for conditions that have historically been managed through hearing aids or cochlear implants.
Sensorion has expressed its commitment to advancing Audiogene through further clinical development and looks forward to sharing more comprehensive data as the trial progresses. The company’s dedication to addressing unmet medical needs in audiology underscores its position at the forefront of innovation in this critical field. Investors and stakeholders will be closely monitoring the ongoing developments of this promising gene therapy.
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Business Wire French Language News published ‘Sensorion annonce des données préliminaires positives de la première cohorte de l'essai clinique de Phase 1/2 de thérapie génique Audiogene’ at 2025-07-01 05:30. Please write a detailed article about this news in a polite tone with relevant information. Please reply in English with the article only.