Advanced Paternal Age and its Impact on IVF Outcomes Revealed at ESHRE 41st Annual Meeting
London, UK – June 29, 2025 – New research presented at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has shed light on a potentially significant factor influencing the success of In Vitro Fertilization (IVF) cycles utilizing donor eggs: the paternal age. The findings suggest a correlation between older paternal age and an increased risk of miscarriage, as well as a reduction in live birth rates among couples undergoing treatment with donor eggs.
The study, detailed in a press release fromprnewswire.com, investigated a substantial cohort of IVF cycles where donor eggs were used. This specific focus is crucial, as it helps to isolate the potential impact of paternal age by controlling for variables related to the egg donor’s age and reproductive health. The research meticulously analyzed data to identify any links between the age of the intended father and the ultimate reproductive outcomes.
Results indicated that as the paternal age increased, there was a discernible rise in the likelihood of a pregnancy resulting in miscarriage. Furthermore, the study observed a corresponding decrease in the rates of live births in these cases. While the exact biological mechanisms underpinning this association require further investigation, researchers hypothesize that factors related to sperm quality, such as DNA integrity, may play a role. As men age, the quality of their sperm can potentially decline, which could have downstream effects on embryo development and the successful continuation of a pregnancy.
These findings are of particular importance for individuals and couples considering fertility treatments, especially those utilizing donor gametes. It underscores the comprehensive nature of factors that can influence IVF success and highlights the need for a holistic approach to fertility planning, considering both maternal and paternal contributions.
The ESHRE annual meeting serves as a vital platform for the dissemination of cutting-edge research in reproductive medicine, bringing together leading experts to discuss the latest advancements and findings. This study contributes valuable insights to the ongoing discourse surrounding age-related fertility challenges and the optimization of IVF protocols.
Further research is anticipated to delve deeper into the specific biological pathways involved and to explore potential strategies that might mitigate these observed risks. In the meantime, these findings encourage open and informed conversations between patients and fertility specialists about all contributing factors to successful conception and pregnancy.
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www.prnewswire.com published ‘ESHRE 41st Annual Meeting: Older paternal age linked to higher miscarriage risk and lower live birth rates in donor egg IVF cycles’ at 2025-06-29 22:01. Please write a detailed article about this news in a polite tone with relevant information. Please reply in English with the article only.